46. Carbonate-Bearing Ionizable Lipids for mRNA Delivery to Splenic NK Cells. Shiqi Wu† Lu Shi†, Kexin Su, Lixin Lin, Xinxin Yan, Yiran Zhang, Tianrui Gu, Zichuan Wang, Tengfei Xu, Shuai Liu*. Journal of the American Chemical Society, 2025, DOI: 10.1021/jacs.5c01389. (Cover Feature)

45. A Versatile Strategy to Transform Cationic Polymers for Efficient and Organ-Selective mRNA. Lixin Lin†, Kexin Su†, Xinyue Zhang, Lu Shi, Xinxin Yan, Qiuli Fu, Ke Yao*, Daniel J. Siegwart*, and Shuai Liu*. Angewandte Chemie International Edition, 2025, 64, e202500306.

44. Aminolysis of Highly Branched Poly(β-amino ester)s for Efficient mRNA Delivery.Haiyang Yong†, Zhili Li†, Lixin Lin, Shuai Liu*, Chao Feng, Songmei Geng, Tao Fu*, Zhengju Chen, and Dezhong Zhou*. Chemistry of Materials, 2025, 37, 2827-2835.

43. Interaction design in mRNA delivery systems. Mengyao Yu, Lixin Lin, Dezhong Zhou*, Shuai Liu*. Journal of Controlled Release, 2025, 377, 413-426.

42.Principles of lipid nanoparticle design for mRNA delivery. Yiran Zhang† Xinyue Zhang† Yongsheng Gao*, Shuai Liu*. BMEMat, 2025, 3, e12116.

41. Paracyclophane-based ionizable lipids for efficient mRNA delivery in vivo. Shiqi Wu, Kexin Su, Xinxin Yan, Lu Shi, Lixin Lin, En Ren, Jingjing Zhou, Chao Zhang, Yanmin Song, Shuai Liu*. Journal of Controlled Release, 2024, 376, 395-401.

40. Tailoring Highly Branched Poly(β-amino ester)s for Efficient and Organ-Selective mRNA Delivery. Haiyang Yong†, Lixin Lin†, Zhili Li, Rui Guo, Chenfei Wang, Shuai Liu*, Dezhong Zhou*. Nano Letters, 2024, 24, 9368-9376.

39. Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation. Kexin Su, Lu Shi, Tao Sheng, Xinxin Yan, Lixin Lin, Chaoyang Meng, Shiqi Wu, Yuxuan Chen, Yao Zhang, Chaorong Wang , Zichuan Wang, Junjie Qiu, Jiahui Zhao, Tengfei Xu, Yuan Ping*, Zhen Gu*, Shuai Liu*. Nature Communications, 2024, 15, 5659.

38. An overview of lipid constituents in lipid nanoparticle mRNA delivery systems. Shiqi Wu, Lixin Lin, Lu Shi, Shuai Liu*. WIREs Nanomedicine and Nanobiotechnology, 2024, 16, e1978.

37. One-Component Cationic Lipids for Systemic mRNA Delivery to Splenic T Cells. Xinyue Zhang†, Kexin Su†, Shiqi Wu†, Lixin Lin, Shun He, Xinxin Yan, Lu Shi, Shuai Li*. Angewandte Chemie International Edition, 2024, 63, e202405444.

36. Zwitterionic materials for nucleic acid delivery and therapeutic applications. Shun He, Shuai Liu*. Journal of Controlled Release, 2024, 365, 919-935.

35. Enzymatically Activatable Polymers for Disease Diagnosis and Treatment. Bin Ma, Jiahao Shi, Yuhe Zhang, Zhili Li, Haiyang Yong, Ya-Nan Zhou*, Shuai Liu*, Sigen A*, Dezhong Zhou*. Advanced Materials, 2024, 36, 2306358.

34. Engineering siRNA therapeutics: challenges and strategies. Syed Saqib Ali Zaidi, Faria Fatima, Syed Aqib Ali Zaidi, Dezhong Zhou*, Wuquan Deng*, Shuai Liu*. Journal of Nanobiotechnology, 2023, 21, 381.

33. Targeting materials and strategies for RNA deliver. Lixin Lin†, Kexin Su†, Qiang Cheng, Shuai Liu*. Theranostics, 2023, 13, 4667-4693.

32. Branched hydrophobic tails in lipid nanoparticles enhance mRNA delivery for cancer immunotherapy. Yunfeng Yan* , Xiaomin Liu, Longyu Wang, Chengfan Wu, Qi Shuai, Yanmei Zhang, Shuai Liu. Biomaterials, 2023, 301, 122279.

31. Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery. Xu Wang, Shuai Liu, Yehui Sun, Xueliang Yu, Sang M. Lee , Qiang Cheng, Tuo Wei, Junyu Gong, Joshua Robinson, Di Zhang, Xizhen Lian, Pratima Basak, Daniel J. Siegwart*. Nature Protocol, 2023, 18, 265-291.

30. Genetic Engineering of Adipose-Derived Stem Cells Using Biodegradable and Lipid-Like Highly Branched Poly(β-amino ester)s. Qiuxia Li†, Litao Sun†, Xiaobei Huang†, Shuai Liu*, Haiyang Yong, Chenfei Wang, Jianzhong Li*, Dezhong Zhou*. ACS Macro Letters, 2022, 11, 636-642.

29. Lipid Nanoparticle (LNP) Chemistry  Can Endow Unique In Vivo RNA Delivery Fates within the Liver That Alter Therapeutic Outcomes in a Cancer Model. Lindsay T. Johnson, Di Zhang, Kejin Zhou, Sang M. Lee, Shuai Liu, Sean A. Dilliard, Lukas Farbiak, Sumanta Chatterjee, Yu-Hsuan Lin, Daniel J. Siegwart*. Molecular Pharmaceutics, 2022, 19, 3973-3986.

28. Membrane-destabilizing ionizable phospholipids for organ selective mRNA delivery and CRISPR-Cas gene editing. Shuai Liu†, Qiang Cheng†, Tuo Wei , Xueliang Yu, Lindsay T. Johnson, Lukas Farbiak, Daniel J. Siegwart *. Nature Materials, 2021, 20, 701-710.

27. Zwitterionic Phospholipidation of Cationic Polymers Facilitates Systemic mRNA Delivery to Spleen and Lymph Nodes. Shuai Liu, Xu Wang, Xueliang Yu, Qiang Cheng, Lindsay T. Johnson, Sumanta Chatterjee, Di Zhang,Sang M. Lee, Yehui Sun, Ting-Chih Lin, John L. Liu, Daniel J. Siegwart*. Journal of the American Chemical Society, 2021, 143, 21321-21330.

26. Zinc(II)-Cyclen Multifunctional Complex Module-Mediated Polycation-Based High-Performance pDNA Vectors. Zhaoming Chen, Shuai Liu, Weijie Liu, Peng Jiang, Lan Wang, Jiaqi Li, Hao Zhou*, Tianying Guo*. ACS Biomaterials Science & Engineering, 2021, 7, 5678-5689.

25. Hydrophobic Optimization of Functional Poly(TPAE-co-suberoyl chloride) for Extrahepatic mRNA Delivery following Intravenous Administration. Xueliang Yu, Shuai Liu, Qiang Cheng, Sang M. Lee, Tuo Wei, Di Zhang, Lukas Farbiak, Lindsay T. Johnson, Xu Wang, Daniel John Siegwart*. Pharmaceutics, 2021, 13, 1914.

24. Ag(I) Pyridine-Amidoxime Complex as the Catalysis Activity Domain for the Rapid Hydrolysis of Organothiophosphate-Based Nerve Agents: Mechanistic Evaluation and Application. Sujuan Zheng+, Jianping Pan+, Junhao Wang, Shuai Liu, Tongtong Zhou, Lan Wang, Huiting Jia, Zhaoming Chen, Qian Peng*, Tianying Guo*. ACS Applied Materials & Interfaces, 2021, 13, 34428-34437.

23. Zinc(II)‐Dipicolylamine Analogs Mediated PEI1.8k/pDNA Vector: Effect of Ligand Structure on the Gene Transport Process. Huiting Jia, Xindong Wang, Zhaoming Chen, Shuai Liu, Tongtong Zhou, Hao Zhou, Tianying Guo*. Macromolecular Bioscience, 2021, 21, 2100048.

22. Zn(II)-Dipicolylamine analogues with amphiphilic side chains endow low molecular weight PEI with high transfection performance. Zhaoming Chen, Xindong Wang, Shuai Liu, Yumeng Li, Hao Zhou, Tianying Guo*. Biomaterials Science, 2021, 9, 3090-3099.

21. A Systematic study of unsaturation in lipid nanoparticles leads to improved mRNA transfection in vivo. Sang M. Lee, Qiang Cheng, Xueliang Yu, Shuai Liu, Lindsay T. Johnson, Daniel J. Siegwart*. Angewandte Chemie International Edition, 2021, 60, 5848-5853.

20. Lipid‐Modified Aminoglycosides for mRNA Delivery to the Liver. Xueliang Yu, Shuai Liu, Qiang Cheng, Tuo Wei, Sang Lee, Di Zhang, Daniel J. Siegwart*. Advanced Healthcare Materials, 2020, 9, 1901487

19. Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo. Hu Xiong*, Shuai Liu, Tuo Wei, Qiang Cheng, Daniel J. Siegwarta*. Journal of Controlled Release, 2020, 325, 198-205.

18. Rapid hydrolysis of nerve agent simulants by molecularly imprinted porous crosslinked polymer incorporating mononuclear zinc (II)-picolinamine-amidoxime module. Jianping Pan, Shuai Liu, Huiting Jia, Jixiang Yang, Meng Qin, Tongtong Zhou, Zhaoming Chen, Xiaoxia Jia, Tianying Guo*. Journal of Catalysis, 2019, 380, 83-90.

17. Multifunctional oligomer immobilized on quartz crystal microbalance: a facile and stabilized molecular imprinting strategy for glycoprotein detection. Xian Zhang, Shuai Liu, Jianping Pan, Huiting Jia, Zhaoming Chen, Tianying Guo*. Analytical and Bioanalytical Chemistry, 2019, 411, 3941-3949.

16. Highly branched poly (β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cell. Shuai Liu†, Yongsheng Gao†, Dezhong Zhou†*, Ming Zeng, Fatma Alshehri, Ben Newland, Jing Lyu, Jonathan O’Keeffe-Ahern, Udo Greiser, Tianying Guo*, Fengzhi Zhang, Wenxin Wang*. Nature Communications, 2019, 10, 3307.

15. Zinc coordinated cationic polymers break up the paradox between low molecular weight and high transfection efficacy. Shuai Liu*, Huiting Jia, Jixiang Yang, Jianping Pan, Huiyun Liang, Liheng Zeng, Hao Zhou, Jiatong Chen, Tianying Guo*. Biomacromolecules, 2018, 19, 4270-4276.

14. Zinc coordination substitute amine: A non-cationic platform for efficient and safe gene delivery. Shuai Liu, Huiting Jia, Jixiang Yang, Jianping Pan, Huiyun Liang, Liheng Zeng, Hao Zhou, Jiatong Chen, Tianying Guo*. ACS Macro Letters, 2018, 7, 868-874.

13. Virus spike and membrane-lytic mimicking nanoparticles for high cell binding and superior endosomal escape. Shuai Liu, Jixiang Yang, Huiting Jia,Hao Zhou, Jiatong Chen, Tianying Guo*. ACS Applied Materials & Interfaces, 2018, 10, 23630-23637.

12. Facile fabrication of superhydrophobic nanocomposite coatings based on water-based emulsion latex. Jixiang Yang, Huiyun Liang, Liheng Zeng, Shuai Liu, Tianying Guo*. Advanced Materials Interfaces, 2018, 5, 1800207.

11. Alkylated branched poly(β-amino esters) demonstrate strong DNA encapsulation, high nanoparticle stability and robust gene transfection efficacy. Shuai Liu†, Zhibing Sun†, Dezhong Zhou*, Tianying Guo*. Journal of Materials Chemistry B, 2017, 5, 5307-5310.

10. Bioreducible zinc(II) coordinative polyethylenimine with low molecular weight for robust gene delivery of primary and stem cells. Shuai Liu†, Dezhong Zhou†, Jixiang Yang, Hao Zhou, Jiatong Chen, Tianying Guo*. Journal of the American Chemical Society, 2017, 139, 5102-5109.

9. Biodegradable highly branched poly(β-Amino ester)s for targeted cancer cell gene transfection. Shuai Liu, Yongsheng Gao, Sigen A, Dezhong Zhou*, Udo Greiser, Tianying Guo*, Rui Guo, Wenxin Wang*. ACS Biomaterials Science & Engineering, 2017, 3, 1283-1286.

8. N,N,N-trimethylchitosan modified with well defined multifunctional polymer modules used as pDNA delivery vector. Hongqi Rena, Shuai Liua, Jixiang Yanga, Xian Zhanga, Hao Zhoub, Jiatong Chenb, Tianying Guo*. Carbohydrate Polymers, 2016, 137, 222-230.

7. Multifunctional oligomer incorporation: a potent strategy to enhance the transfection activity of poly(l-lysine).  Shuai Liu, Jixiang Yang, Hongqi Ren, Jonathan O’Keeffe-Ahern, Dezhong Zhou, Hao Zhou, Jiatong Chen, Tianying Gu0. Biomaterials Science, 2016, 4, 522-532.

6. Polycation-based ternary gene delivery system. Shuai Liu, Tianying Guo*. Current Drug Metabolism, 2015, 16, 152-165.

5. Fluorescently labeled degradable thermoplastic polyurethane elastomers: Visual evaluation for the degradation behavior. Zhengsheng Liu, Shuai Liu, Heguang Shi, Hongqi Ren, Ruiyu Wang, Jixiang Yang, Tianying Guo*. Journal of Applied Polymer Science, 2015, 132, 42519.

4. Novel imprinted nanocapsule with highly enhanced hydrolyticactivity for organophosphorus pesticide degradation and elimination. Heguang Shi, Ruiyu Wang, Jixiang Yang, Hongqi Ren, Shuai Liu, Tianying Guo*. European Polymer Journal, 2015, 72, 190-201.

3. Evaluation of the effects of amphiphilic oligomers in PEI based ternary complexes on the improvement of pDNA delivery. Wenhao Chi, Shuai Liu, Jixiang Yang, Ruiyu Wang, Hongqi Ren, Hao Zhou*, Jiatong Chen, Tianying Guo*. Journal of Materials Chemistry B, 2014, 2, 5387-5396.

2. One-step synthesis of reactant-product-dual-template imprinted capsules as phosphotriesterase mimetic enzymes for pesticide elimination. Yong Guo, Ruiyu Wang, Wenhao Chi, Shuai Liu, Heguang Shi, Tianying Guo*. RSC Advances, 2014, 4, 7881-7884.

1. Construction of a novel macroporous imprinted biosensor based on quartz crystal microbalance for ribonuclease A detection. Shuai Liu, Dezhong Zhou, Tianying Guo*. Biosensors & Bioelectronics, 2013, 42, 80-86.